Chlorambucil for cats & dogs is an immunosuppressive and anticancer medication. It treats cancers like leukemia, lymphoma, and multiple myeloma. It also supports the treatment of immune-mediated diseases such as inflammatory bowel disease.
Veterinarians often prescribe chlorambucil for cats/dogs “off label.” Follow your veterinarian’s directions carefully, as they may differ from the label instructions.
How is Chlorambucil Given?
Administering
Give chlorambucil orally as a tablet or compounded liquid, with food. Avoid crushing or splitting tablets yourself. Measure liquid doses precisely.
Wear gloves when handling the medication, especially if you are pregnant or nursing. Dispose of gloves and waste in sealed bags. Prevent contact with your pet’s bodily fluids for several days after administration, and wash thoroughly if exposure occurs.
What to Do if You Miss a Dose
If you miss a dose, contact your veterinarian for instructions. Proper dosing is essential for effectiveness and safety.
Potential Side Effects
Common side effects include fur loss or coat changes in certain breeds. Serious side effects may involve:
- Lethargy or depression
- Appetite loss
- Vomiting or diarrhea
- Bruising or bleeding
- Shortness of breath or seizures
Side effects may appear immediately, while benefits develop over a few weeks.
Risk Factors for Chlorambucil Use
Avoid using it if allergic to alkylating agents, with bone marrow disease, or active infections. Do not use in pregnant or lactating animals. Use caution with elderly pets or those with chronic diseases. Avoid vaccinations during treatment unless advised by your veterinarian.
Gloves must be worn during handling. Pregnant women should not handle chlorambucil. Dispose of waste securely, and avoid direct contact with the drug or pet fluids.
Drug Interactions with Chlorambucil
Chlorambucil interacts with myelosuppressive agents and vaccines. Inform your veterinarian of any medications, supplements, or herbal remedies your pet is taking.
Monitoring During Treatment
Veterinarians perform baseline blood tests, urinalysis, and follow-up blood counts every 1-3 months to monitor treatment. Regular check-ups ensure the medication’s effectiveness and safety.
How to Store Chlorambucil
Store chlorambucil in a refrigerator between 36°F and 46°F (2°C and 8°C), protected from light. Keep tablets at room temperature (up to 86°F or 30°C) for no more than a week. Liquid forms must stay refrigerated.
Emergency Instructions
Treat any overdose as an emergency. If you suspect an overdose or adverse reaction, contact your veterinarian or an emergency facility immediately.
Chlorambucil is a highly effective veterinary medication used to treat various conditions, including certain types of cancer and autoimmune diseases in pets. This veterinary medication works by suppressing the immune system, which can help manage diseases like lymphoma, leukemia, and other chronic illnesses. When administered properly, Chlorambucil can improve the quality of life for pets suffering from these serious health issues.
