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Tenvir - Tenofovir fumarate Tablets


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Tenvir

Tenvir-EM tablets contain emtricitabine and tenofovir, which are antiretroviral drugs used to treat HIV infection, to prevent or slow down the spread of infection. Tenvir-EM (Tenofovir Disoproxil Fumarate/Emtricitabine) is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults. Each film coated tablet contains 300mg of Tenofovir Disoproxil Fumarate and 200mg of Emtricitabine.
  • Brand Name: Tenvir
  • Generic Name: Tenofovir disoproxil fumarate
  • Contents: Tenofovir disoproxil fumarate 300mg
  • Form: Tablets
  • Manufacturer Cipla
  • Other Brand Name: Viread
  • Pricing: Price Per Pack of 30 Tablets

TENVIR Tablets

Each film-coated Tenvir tablet contains 
Tenofovir disoproxil fumarate ….. 300 mg

INDICATIONS

TENVIR Tablets are is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection.

The following point should be considered when initiating therapy with tenofovir for the treatment of HIV-1 infection:

* Tenofovir should not be used in combination with tenofovir /emtricitabine or emtricitabine /tenofovir/efavirenz (see WARNINGS AND PRECAUTIONS)


Tenvir Doses 

The dose of TENVIR Tablets is 300 mg once daily taken orally, without regard to food.


Dose Adjustment for Renal Impairment

Significantly increased drug exposures occurred when tenofovir disoproxil fumarate was administered to patients with moderate to severe renal impairment. The dosing interval of tenofovir disoproxil fumarate should be adjusted in patients with baseline creatinine clearance <50 mL/min using the recommendations in Table 2 . The safety and effectiveness of these dosing interval adjustment recommendations have not been clinically evaluated; therefore, clinical response to treatment and renal function should be closely monitored in these patients. 

No dose adjustment is necessary for patients with mild renal impairment (creatinine clearance 50–80 mL/min). Routine monitoring of calculated creatinine clearance and serum phosphorus should be performed in patients with mild renal impairment

1.Calculated using ideal (lean) body weight.

2.Generally once weekly assuming three hemodialysis sessions a week of approximately 4 hours duration. Tenofovir disoproxil fumarate should be administered following completion of dialysis.

The pharmacokinetics of tenofovir have not been evaluated in non-hemodialysis patients with creatinine clearance <10 mL/min; therefore, no dosing recommendation is available for these patients.


CONTRAINDICATIONS
None.


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