WHAT IS ESTRAMUSTINE ?
Estramustine 140mg is a combination anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug classified as an “antimicrotubule agent,” and it also has hormonal therapy features. It is cell cycle specific. It acts on the microtubule structure and function of the cell by attaching to the microtubule-associated proteins. Antimicrotubule agents are also signal transduction inhibitors and are sometimes referred to as targeted therapy.
MEDICINE USES :
Estramustine is used to treat prostate cancer that has progressed or spread. It is made up of a combination of the anti-neoplastic substance – nornitrogen mustard and the estrogen derivative – estradiol phosphate. This design was to target cancer cells with estrogen receptors on their surface. However, it was found to be active against estrogen receptor-negative tumor cells as well.
ESTRAMUSTINE COMMON SIDE EFFECTS :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Anxiety; breast enlargement or tenderness; bruising; chest pain; diarrhea; hair thinning; headache; hoarseness; leg cramps; loss of appetite; mood swings; nausea; sleep loss; sore throat; stomach ache; vein inflammation; watery eyes.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; chest pain; easy bruising; impotence; numbness of an arm or leg; stroke; sudden leg pain; sudden, severe headache; swelling of the feet or ankles.