Erythropoietin is a glycoprotein hormone produced by the kidney. It is synthesized in response to hypoxia. In anaemia, renal secretion of erythropoietin increases rapidly. It is prepared by DNA recombinant technology. Erythropoietin acts on the most primitive precursors or progenitors of erythrocytes by acting on the cell membrane receptors. Erythropoietin stimulates erythrocytic process as well as their maturation and differentiation.
Erythropoietin is the chemical substance known as glycoprotein hormone which is released by Kidney in human body. Erythropoietin plays important role red blood corpuscles. Erythropoietin helps in the definitive Erythropoiesis to take place in the body. It is released when hypoxia triggered in the body to accelerate the production of RBC.
Erythropoietin plays an important role in brain's response to neuronal injury, it also involved in the wound healing processes. Erythropoietin is prepared by DNA recombinant technology. Erythropoietin has been shown to deploy the effect by binding to the (EpoR) Erythropoietin receptor.
Erythropoietin regulates erythropoiesis by stimulating the differentiation and proliferation of erythroid precursors, stimulating the release of reticulocytes into the circulation, and synthesis of cellular haemoglobin. Recombinant human erythropoietin is available as epoetin alfa and epoetin beta which are used in the management of anaemias associated with CRF, cancer chemotherapy and anti-AIDS drug zidovudine..
Epoeitin Alfa: Eprex , epogen
epoietin beta: MIRCERA, Neorecorman and recorman
Miscellaneous: Wepox , Espogen, zyrop, erypro safe, vinitor
majorly used in treatment anemia resulting from chronic kidney disease
chron's disease and ulcer colitis
Arthralgia, Flu like syndrome, urtcaria.
Hypertensive crisis with encephalopathy like symptoms e.g. confusion, headache, generalized seizures, thrombosis.
Eporise - Maufactured by Zuvents
Relipoietin - Manufactured By Reliance LifeSciences
Eprex - Manufactured by Ethnor Ltd (Johnson & Johnson)
Neo Recormon - Manufactured By Roche Pharmaceuticals
Erypro - Manufactured By Biocon